通过芹菜素靶向 PI3K/Akt/mTOR 轴预防癌症。
Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention.
机构信息
Department of Pathology, Northwestern University, Chicago, IL 60611, USA.
出版信息
Anticancer Agents Med Chem. 2013 Sep;13(7):971-8. doi: 10.2174/18715206113139990119.
Abstract
Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin's inhibition of the PI3K/Akt/mTOR signaling pathways.
摘要
天然产物是抗癌先导分子的重要来源，高膳食摄入水果和蔬菜与降低某些癌症的风险有关。许多人致力于识别和开发植物源性膳食成分作为化学预防剂。其中，芹黄素是一种存在于各种水果和绿叶蔬菜中的天然类黄酮，已被证明具有显著的抗氧化、抗炎和抗癌特性。这篇综述总结了芹黄素在细胞和分子水平上的抗癌和化学预防作用、它的化学结构和性质，重点是与芹黄素抑制 PI3K/Akt/mTOR 信号通路相关的机制。
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