Wilson C, Thakore A, Isenberg D, Ebringer A
Immunology Section, King's College, London, UK.
Rheumatol Int. 1997;16(5):187-9. doi: 10.1007/BF01330294.
In a survey of 89 RA patients, carried out under code, Proteus mirabilis was isolated from the urine of 63% (47/75) of female (P < 0.001) and 50% (7/14) of male patients (P < 0.001), compared to a frequency of isolation in healthy women of 32% (38/119) and 11% (13/115) in healthy men. There was no significant difference in isolation rates between 37 non-RA patients and healthy controls. Sera from 20 patients with RA and 20 healthy controls were tested against P. mirabilis and Escherichia coli by an enzyme-linked immunosorbent assay. Antibodies against P. mirabilis but not to E. coli were significantly higher in the RA patients than in healthy controls (P < 0.001). Furthermore, a positive correlation was found between high anti-Proteus antibody levels in serum samples and the number of Proteus colony-forming units obtained from urine specimens of the 20 RA patients (r = +0.714, P < 0.001). These results support the suggestion of an aetiopathogenic role for P. mirabilis in RA.
在一项对89名类风湿关节炎（RA）患者进行的编码调查中，奇异变形杆菌从63%（47/75）的女性患者尿液（P < 0.001）和50%（7/14）的男性患者尿液中分离出来，而健康女性的分离频率为32%（38/119），健康男性为11%（13/115）。37名非RA患者与健康对照的分离率无显著差异。通过酶联免疫吸附试验对20名RA患者和20名健康对照的血清进行了针对奇异变形杆菌和大肠杆菌的检测。RA患者中针对奇异变形杆菌而非大肠杆菌的抗体显著高于健康对照（P < 0.001）。此外，在血清样本中高抗变形杆菌抗体水平与从20名RA患者尿液标本中获得的变形杆菌菌落形成单位数量之间发现正相关（r = +0.714，P < 0.001）。这些结果支持奇异变形杆菌在RA发病机制中具有病因学作用的观点。
