Cope A P, Jones A, Brozovic M, Shafi M S, Maini R N
Department of Rheumatology, Charing Cross Hospital, Fulham, London, United Kingdom.
Ann Rheum Dis. 1992 Jun;51(6):803-4. doi: 10.1136/ard.51.6.803.
A 59 year old woman presented with an influenza-like illness preceding signs and symptoms strongly suggestive of systemic lupus erythematosus (SLE), which progressed over several months. Owing to these influenza-like symptoms, a viral cause of her illness was sought. Human parvovirus B19 serology was positive and antibodies to DNA were detected by two different methods. This patient is believed to be the first report of human parvovirus B19 infection coinciding with the onset of SLE. The evidence for B19 virus and the part it plays in autoimmunity and arthritis is discussed.
一名59岁女性出现类似流感的疾病,随后出现强烈提示系统性红斑狼疮(SLE)的体征和症状,且在数月内病情进展。由于这些类似流感的症状,对其疾病的病毒病因进行了探寻。人细小病毒B19血清学检测呈阳性,且通过两种不同方法检测到了抗DNA抗体。据信该患者是首例人细小病毒B19感染与SLE发病同时出现的报告。文中讨论了B19病毒的证据及其在自身免疫和关节炎中所起的作用。