来自红海海绵Hyrtios erectus的细胞毒性生物碱A - C（海鞘直立海绵素A - C）

Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge hyrtioserectus.

作者信息

Youssef Diaa T A

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

出版信息

J Nat Prod. 2005 Sep;68(9):1416-9. doi: 10.1021/np050142c.

DOI:10.1021/np050142c

PMID:16180827

Abstract

A Red Sea specimen of the marine sponge Hyrtios erectus was found to contain three new alkaloids, hyrtioerectines A-C (1-3). Hyrtioerectine A (1) possesses the carbon bond-linked moieties 6-hydroxy beta-carboline and 6-hydroxyindole. The structure elucidation of 1-3 was based on intensive study of their spectral data including 1D (1H and 13C) and 2D (1H-1H COSY, HOHAHA, NOESY, ROESY, HMQC, and HMBC) NMR, together with high-resolution mass spectra. Hyrtioerectines A-C were moderately cytotoxic.

摘要

红海的一种海洋海绵直立扁枝海绵（Hyrtios erectus）被发现含有三种新生物碱，即直立扁枝海绵碱A - C（1 - 3）。直立扁枝海绵碱A（1）具有通过碳键连接的6 - 羟基β-咔啉和6 - 羟基吲哚部分。对1 - 3的结构解析基于对其光谱数据的深入研究，包括一维（1H和13C）和二维（1H - 1H COSY、HOHAHA、NOESY、ROESY、HMQC和HMBC）核磁共振谱，以及高分辨率质谱。直立扁枝海绵碱A - C具有中等细胞毒性。