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来自红海海绵直立希氏海绵的基于四环三萜的抗增殖代谢产物。

Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.

作者信息

Elhady Sameh S, Al-Abd Ahmed M, El-Halawany Ali M, Alahdal Abdulrahman M, Hassanean Hashim A, Ahmed Safwat A

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

出版信息

Mar Drugs. 2016 Jul 8;14(7):130. doi: 10.3390/md14070130.

DOI:10.3390/md14070130
PMID:27399730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4962020/
Abstract

Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoceratida) collected from the Red Sea, Egypt. The structures of the isolated compounds were elucidated on the basis of their spectroscopic data and comparison with reported NMR data. Compounds 1-9 exhibited considerable antiproliferative activity against breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT-116) and hepatocellular carcinoma cells (HepG2). Compounds 3, 5 and 9 were selected for subsequent investigations regarding their mechanism of cell death induction (differential apoptosis/necrosis assessment) and their influence on cell cycle distribution.

摘要

从采集自埃及红海的海绵直立扁枝海绵（Dictyoceratida目）中分离出了两种新的倍半萜类似物，即12-乙酰氧基-16-表hyrtiolide（1）和12β-乙酰氧基-16β-甲氧基-20α-羟基-17-鲨烯-19,20-内酯（2），它们含有基于鲨烯烷的骨架，以及七种先前报道的鲨烯烷型倍半萜（3-9）。根据分离出的化合物的光谱数据并与已报道的核磁共振数据进行比较，阐明了其结构。化合物1-9对乳腺腺癌（MCF-7）、结肠直肠癌（HCT-116）和肝癌细胞（HepG2）表现出相当强的抗增殖活性。选择化合物3、5和9进行后续研究，以探讨其诱导细胞死亡的机制（差异凋亡/坏死评估）及其对细胞周期分布的影响。

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