Han Hee Dong, Shin Byung Cheol, Choi Ho Suk
Advanced Materials Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea.
Eur J Pharm Biopharm. 2006 Jan;62(1):110-6. doi: 10.1016/j.ejpb.2005.07.006. Epub 2005 Sep 22.
In the field of the temperature sensitive drug delivery systems, we studied on the surface modification of liposomes by using poly(N-isopropylacrylamide-co-acrylamide) (PNIPAM-AAM) and polyethyleneglycol (PEG) to increase the release of doxorubicin (DOX) from liposomes and prolong the stability of liposomes in the presence of serum. The release of DOX from the PNIPAM-AAM/PEG modified liposomes is enhanced around the transition temperature of the polymer. In addition, the stability of the PNIPAM-AAM/PEG modified liposomes in serum shows a high level comparing with polymer unmodified liposomes. These results suggest that the modification on the surface of liposomes with both PNIPAM-AAM and PEG enhances the drug release from liposomes and reduces the protein adsorption in serum.
在温度敏感型药物递送系统领域，我们研究了使用聚（N-异丙基丙烯酰胺-共-丙烯酰胺）（PNIPAM-AAM）和聚乙二醇（PEG）对脂质体进行表面修饰，以增加阿霉素（DOX）从脂质体中的释放，并延长脂质体在血清存在下的稳定性。DOX从PNIPAM-AAM/PEG修饰的脂质体中的释放在聚合物的转变温度附近增强。此外，与未用聚合物修饰的脂质体相比，PNIPAM-AAM/PEG修饰的脂质体在血清中的稳定性较高。这些结果表明，用PNIPAM-AAM和PEG对脂质体表面进行修饰可增强药物从脂质体中的释放，并减少血清中的蛋白质吸附。
