Jaffe Craig, Bush Kristen R, Straits-Troster Kristy, Meredith Charles, Romwall Lisa, Rosenbaum Gail, Cherrier Monique, Saxon Andrew J
Department of Psychiatry and Behavioral Sciences, University of Washington, 12013 Pinehurst Way NE, Seattle, WA 98125, USA.
J Addict Dis. 2005;24(3):133-52. doi: 10.1300/J069v24n03_11.
Methamphetamine-dependent inpatients (N = 51) were screened for childhood attention deficit hyperactivity disorder (ADHD) using the Wender Utah Rating Scale upon admission to 30-day inpatient treatment. Baseline assessments included neuropsychological tests of executive function, memory, information processing, verbal fluency, attention, motor skills, and the Brief Symptom Inventory (BSI), a measure of psychiatric symptomatology. The thirty-six participants (70.6%) screening positive for ADHD reported significantly more frequent methamphetamine use prior to baseline. Baseline cognitive functioning was similar between groups, but the presumptive ADHD participants exhibited significantly worse psychiatric symptomatology. At three-week follow- up, 41 participants (80.4%) repeated the neuropsychological battery and BSI. All 10 non-completers screened positive for ADHD. The entire sample improved with abstinence in most neuropsychological domains except memory. The presumptive ADHD group failed to improve on tests of attention. All participants demonstrated significant reductions in psychiatric symptoms with abstinence. Methamphetamine-dependent individuals with ADHD symptoms are common and pose a significant treatment challenge.
对51名甲基苯丙胺依赖住院患者在入院接受30天住院治疗时，使用温德犹他评定量表筛查儿童期注意缺陷多动障碍（ADHD）。基线评估包括执行功能、记忆、信息处理、语言流畅性、注意力、运动技能的神经心理学测试，以及作为精神症状学测量指标的简明症状量表（BSI）。36名（70.6%）ADHD筛查呈阳性的参与者在基线前报告使用甲基苯丙胺的频率显著更高。两组之间的基线认知功能相似，但推定患有ADHD的参与者表现出明显更差的精神症状。在三周随访时，41名参与者（80.4%）重复进行了神经心理学测试和BSI。所有10名未完成者ADHD筛查均呈阳性。除记忆外，整个样本在大多数神经心理学领域随着戒断而有所改善。推定患有ADHD的组在注意力测试中没有改善。所有参与者在戒断后精神症状均显著减轻。有ADHD症状的甲基苯丙胺依赖个体很常见，并且带来重大的治疗挑战。
