Melchior F M, Srinivasan R S, Charles J B
Laboratoire de Médecine Aérospatiale, Centre d'Essais en Vol, Brétigny S/Orge, France.
Am J Physiol. 1992 Jun;262(6 Pt 2):H1920-33. doi: 10.1152/ajpheart.1992.262.6.H1920.
This paper deals with the short-term response of the human cardiovascular system to orthostatic stresses in the context of developing a mathematical model of the overall system. It discusses the physiological issues involved and how these issues have been handled in published cardiovascular models for simulation of orthostatic response. Most of the models are stimulus specific with no demonstrated capability for simulating the responses to orthostatic stimuli of different types. A comprehensive model incorporating all known phenomena related to cardiovascular regulation would greatly help to interpret the various orthostatic responses of the system in a consistent manner and to understand the interactions among its elements. This paper provides a framework for future efforts in mathematical modeling of the entire cardiovascular system.
本文在构建人体心血管系统整体数学模型的背景下，探讨了人体心血管系统对体位性应激的短期反应。文中讨论了相关的生理问题，以及在已发表的用于模拟体位性反应的心血管模型中这些问题是如何处理的。大多数模型是针对特定刺激的，没有显示出模拟不同类型体位性刺激反应的能力。一个包含所有与心血管调节相关已知现象的综合模型，将极大地有助于以一致的方式解释该系统的各种体位性反应，并理解其各组成部分之间的相互作用。本文为未来在整个心血管系统数学建模方面的努力提供了一个框架。
