Richt J A, VandeWoude S, Zink M C, Clements J E, Herzog S, Stitz L, Rott R, Narayan O
Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Clin Infect Dis. 1992 Jun;14(6):1240-50. doi: 10.1093/clinids/14.6.1240.
Borna disease virus (BDV), which seems to be distinct from all other known viruses, exhibits a unique mechanism of pathogenesis. This review highlights several aspects of the biology of infection with this virus and summarizes the preliminary characterization of the agent. Studies on BDV may help to illuminate several important areas of neurobiology, including the mechanisms regulating the replication of a new type of RNA virus in the nuclei of neural cells, the neuroinvasiveness and neurotropism of such viruses, their T cell-mediated immunopathology, tolerance in newborn animals to persistent viral infection of the central nervous system, and behavioral diseases and eating disorders induced by such agents.
博尔纳病病毒（BDV）似乎与所有其他已知病毒不同，具有独特的致病机制。本综述重点介绍了该病毒感染生物学的几个方面，并总结了该病原体的初步特征。对BDV的研究可能有助于阐明神经生物学的几个重要领域，包括调节新型RNA病毒在神经细胞核内复制的机制、此类病毒的神经侵袭性和嗜神经性、其T细胞介导的免疫病理学、新生动物对中枢神经系统持续性病毒感染的耐受性，以及由此类病原体引起的行为疾病和饮食失调。
