University Giessen, Giessen, Germany.
Emerg Infect Dis. 2012 Feb;18(2):234-41. doi: 10.3201/eid1802.111525.
Avian bornavirus (ABV) is the presumed causative agent of proventricular dilatation disease (PDD), a major fatal disease in psittacines. However, the influencing factors and pathogenesis of PDD are not known and natural ABV infection exhibits remarkable variability. We investigated the course of infection in 18 cockatiels that were intracerebrally and intravenously inoculated with ABV. A persistent ABV infection developed in all 18 cockatiels, but, as in natural infection, clinical disease patterns varied. Over 33 weeks, we simultaneously studied seroconversion, presence of viral RNA and antigens, infectious virus, histopathologic alterations, and clinical signs of infection in the ABV-infected birds. Our study results further confirm the etiologic role of ABV in the development of PDD, and they provide basis for further investigations of the pathogenetic mechanisms and disease-inducing factors for the development of PDD.
禽源博尔纳病毒（ABV）被认为是前胃扩张病（PDD）的病原体，该病是鹦鹉类的一种主要致命疾病。然而，PDD 的影响因素和发病机制尚不清楚，并且自然 ABV 感染表现出显著的变异性。我们研究了 18 只虎皮鹦鹉的感染过程，这些鹦鹉通过脑内和静脉接种 ABV。18 只虎皮鹦鹉均发生持续的 ABV 感染，但与自然感染一样，临床疾病模式存在差异。在 33 周的时间里，我们同时研究了 ABV 感染鸟类的血清转化、病毒 RNA 和抗原的存在、感染性病毒、组织病理学改变以及感染的临床症状。我们的研究结果进一步证实了 ABV 在 PDD 发展中的病因作用，并为进一步研究 PDD 发病机制和致病因素提供了依据。
