Richt J A, Herzog S, Pyper J, Clements J E, Narayan O, Bechter K, Rott R
Institut für Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.
Arch Virol Suppl. 1993;7:101-9. doi: 10.1007/978-3-7091-9300-6_9.
This review presents data on the characterization of Borna disease virus (BDV) and its potential as a possible causative agent in humans. The isolation of: (i) BDV-specific cDNA clones that encode various BDV-specific proteins and (ii) partially purified virus particles led to the conclusion that the viral genome consists of negative-sense, single-stranded RNA. The organization of the BDV-specific RNA species appears to be a nested set of overlapping subgenomic RNA transcripts. Furthermore, evidence is presented that BDV can infect humans and may cause certain psychiatric and neurological disorders. This concept is supported by: (i) the finding of virus-specific antibodies in sera of patients with neuropsychiatric diseases and (ii) results obtained during attempts to isolate BDV or a BDV-related agent from the cerebrospinal fluid of seropositive patients.
本综述介绍了博尔纳病病毒（BDV）的特征数据及其作为人类可能致病因子的潜力。（i）编码各种BDV特异性蛋白的BDV特异性cDNA克隆和（ii）部分纯化的病毒颗粒的分离得出结论，病毒基因组由负链单链RNA组成。BDV特异性RNA种类的组织似乎是一组嵌套的重叠亚基因组RNA转录本。此外，有证据表明BDV可感染人类并可能导致某些精神和神经疾病。这一概念得到以下支持：（i）在神经精神疾病患者血清中发现病毒特异性抗体，以及（ii）在试图从血清阳性患者的脑脊液中分离BDV或BDV相关因子时获得的结果。
