卡多龙内酯A和B，两种从长梗南五味子中分离得到的具有独特骨架的新型三萜双内酯。

Kadlongilactones A and B, two novel triterpene dilactones from Kadsura longipedunculata possessing a unique skeleton.

作者信息

Pu Jian-Xin, Xiao Wei-Lie, Lu Yang, Li Rong-Tao, Li Hong-Mei, Zhang Li, Huang Sheng-Xiong, Li Xian, Zhao Qin-Shi, Zheng Qi-Tai, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan.

出版信息

Org Lett. 2005 Oct 27;7(22):5079-82. doi: 10.1021/ol052161j.

DOI:10.1021/ol052161j

PMID:16235962

Abstract

[structure: see text] Two novel triterpene dilactones with an unprecedented rearranged hexacyclic skeleton, kadlongilactones A (1) and B (2), have been isolated from the leaves and stems of Kadsura longipedunculata Finet et Gagnep (Schisandraceae). Their structures were established by comprehensive 1D and 2D NMR spectroscopic analysis, coupled with single-crystal X-ray crystallographic diffraction. Compounds 1 and 2 exerted significant inhibitory effects against human tumor K562 cells with IC(50) = 1.40 and 1.71 microg/mL, respectively.

摘要

[结构：见正文] 从长梗南五味子（五味子科）的叶和茎中分离出两种具有前所未有的重排六环骨架的新型三萜二内酯，卡德龙内酯A（1）和B（2）。它们的结构通过全面的一维和二维核磁共振光谱分析以及单晶X射线晶体学衍射确定。化合物1和2对人肿瘤K562细胞具有显著的抑制作用，IC50分别为1.40和1.71微克/毫升。