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猪布鲁氏菌1330基因组中的IncP岛是通过位点特异性整合获得的。

The IncP island in the genome of Brucella suis 1330 was acquired by site-specific integration.

作者信息

Lavigne Jean-Philippe, Vergunst Annette C, Bourg Gisèle, O'Callaghan David

机构信息

Institut National de la Santé et de la Recherche Médicale, Unité 431, UFR de Médecine, CS 83021, Avenue J. F. Kennedy, 30908 Nimes Cedex 02, France.

出版信息

Infect Immun. 2005 Nov;73(11):7779-83. doi: 10.1128/IAI.73.11.7779-7783.2005.

DOI:10.1128/IAI.73.11.7779-7783.2005
PMID:16239585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1273839/
Abstract

An 18,228-bp region containing open reading frames predicted to be derived from the IncP plasmid or phage ancestors is present in the genomes of Brucella suis biovars 1 to 4, B. canis, B. neotomae, and strains isolated from marine mammals, but not in B. melitensis, B. abortus, B. ovis, and B. suis biovar 5. The presence of circular excision intermediates and the results of an analysis of sequenced bacterial genomes suggest that the region downstream of the guaA gene is a hotspot for site-specific integration of foreign DNA mediated by a CP4-like integrase.

摘要

一个包含预测源自IncP质粒或噬菌体祖先的开放阅读框的18228碱基对区域存在于猪布鲁氏菌1至4型生物变种、犬布鲁氏菌、新墨西哥州布鲁氏菌以及从海洋哺乳动物分离出的菌株的基因组中，但在羊布鲁氏菌、牛布鲁氏菌、绵羊布鲁氏菌和猪布鲁氏菌5型生物变种中不存在。环状切除中间体的存在以及对已测序细菌基因组的分析结果表明，guaA基因下游区域是由CP4样整合酶介导的外源DNA位点特异性整合的热点。

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