麻风病和结核病患者针对卡介苗牛分枝杆菌85A和85B抗原的体液免疫反应。
Humoral responses against the 85A and 85B antigens of Mycobacterium bovis BCG in patients with leprosy and tuberculosis.
作者信息
Van Vooren J P, Drowart A, De Bruyn J, Launois P, Millan J, Delaporte E, Develoux M, Yernault J C, Huygen K
机构信息
Chest Department, Hôpital Erasme, Brussels, Belgium.
出版信息
J Clin Microbiol. 1992 Jun;30(6):1608-10. doi: 10.1128/jcm.30.6.1608-1610.1992.
Abstract
Immunoglobulin G antibodies against the 85A and 85B components of the Mycobacterium bovis BCG antigen 85 complex separated by isoelectric focusing were investigated in serum samples from 129 patients representing the major forms of leprosy, 111 tuberculous patients, and 153 healthy subjects. For both of the antigens, a higher degree of staining was observed for lepromatous leprosy patients and patients with active tuberculosis than for the other groups. Because sera from some healthy subjects recognized the 85A antigen, we suggest that antigen 85B is the most useful component of the antigen 85 complex for the serodiagnosis of the multibacillary forms of leprosy or of the active forms of tuberculosis.
摘要
通过等电聚焦分离出牛分枝杆菌卡介苗抗原85复合物的85A和85B成分后，我们检测了129例代表麻风主要类型的患者、111例结核病患者以及153名健康受试者血清样本中针对这些成分的免疫球蛋白G抗体。对于这两种抗原，瘤型麻风患者和活动性结核病患者的染色程度高于其他组。由于一些健康受试者的血清能识别85A抗原，我们认为抗原85B是抗原85复合物中用于麻风多菌型或结核病活动型血清诊断的最有用成分。
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