具有HIV抑制作用的天然产物。26. 从吴茱萸中提取的喹啉生物碱。
HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana.
作者信息
McCormick J L, McKee T C, Cardellina J H, Boyd M R
机构信息
Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
出版信息
J Nat Prod. 1996 May;59(5):469-71. doi: 10.1021/np960250m.
Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3-5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 microM, respectively), but 3-5 were inactive against HIV-1.
对吴茱萸二氯甲烷 - 甲醇提取物进行生物活性导向分离，得到了两种已知的喹啉生物碱布查平（1）和2，以及三种新的呋喃喹啉生物碱吴茱萸胺A、B和C（3 - 5）。化合物1和2在体外可保护CEM - SS细胞免受HIV - 1的细胞病变效应影响（EC50分别为0.94和1.64微摩尔），但3 - 5对HIV - 1无活性。
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