2型糖尿病患者的不宁腿综合征与睡眠质量

Restless legs syndrome and quality of sleep in type 2 diabetes.

作者信息

Lopes Lívia A, Lins Camila de M M, Adeodato Vanessa G, Quental Diana P, de Bruin Pedro F C, Montenegro Renan M, de Bruin Veralice M S

机构信息

Department of Medicine, Federal University of Ceará, Ceará, Brazil.

出版信息

Diabetes Care. 2005 Nov;28(11):2633-6. doi: 10.2337/diacare.28.11.2633.

DOI:10.2337/diacare.28.11.2633

PMID:16249531

Abstract

OBJECTIVE

To investigate the presence of restless legs syndrome (RLS) and the quality of sleep in a population of type 2 diabetic patients.

RESEARCH DESIGN AND METHODS

The study population was composed of 100 consecutive patients regularly attending a diabetes clinic at the University Hospital of the Federal University of Ceará. The subjects' quality of sleep was assessed by the Pittsburgh Sleep Quality Index, and excessive daytime sleepiness (EDS) was measured by the Epworth Sleepiness Scale. The RLS was diagnosed using the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Other relevant clinical and laboratory parameters were obtained by interview and chart review.

RESULTS

RLS was found in 27% of patients. Poor sleep quality was present in 45% of cases and was associated with age (P = 0.04), peripheral neuropathy (P = 0.001), and RLS (P = 0.000). EDS was found in 26% of patients. Logistic regression analysis revealed an association between RLS and peripheral neuropathy (odds ratio 12.85 [95% CI 2.83-58.40], P = 0.001).

CONCLUSIONS

RLS is common in type 2 diabetic patients and can be a major cause of sleep disruption in these patients.

摘要

目的

调查2型糖尿病患者群体中不安腿综合征（RLS）的存在情况及睡眠质量。

研究设计与方法

研究人群由100名连续就诊于塞阿拉联邦大学大学医院糖尿病门诊的患者组成。采用匹兹堡睡眠质量指数评估受试者的睡眠质量，用爱泼华嗜睡量表测量日间过度嗜睡（EDS）。根据国际不安腿综合征研究组定义的四项最低标准诊断RLS。通过访谈和查阅病历获取其他相关临床和实验室参数。

结果

27%的患者存在RLS。45%的病例睡眠质量差，且与年龄（P = 0.04）、周围神经病变（P = 0.001）和RLS（P = 0.000）相关。26%的患者存在EDS。逻辑回归分析显示RLS与周围神经病变之间存在关联（比值比12.85 [95%可信区间2.83 - 58.40]，P = 0.001）。