Sautour Marc, Miyamoto Tomofumi, Lacaille-Dubois Marie-Aleth
Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Bd Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
Phytochemistry. 2007 Oct;68(20):2554-62. doi: 10.1016/j.phytochem.2007.02.033. Epub 2007 Apr 20.
Six new steroidal saponins (1-6) were isolated from the roots of A. acutifolius L., together with a known spirostanol glycoside (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS and HRESIMS). Compounds 4-7 demonstrated antifungal activity against the human pathogenic yeasts C. albicans, C. glabrata and C. tropicalis with MICs values between 12.5 and 100 microg/ml.
从尖叶天门冬（Asparagus acutifolius L.）的根部分离出6个新的甾体皂苷（1-6），以及1个已知的螺旋甾烷醇糖苷（7）。它们的结构主要通过广泛的光谱分析（一维和二维核磁共振、快原子轰击质谱和高分辨电喷雾电离质谱）得以阐明。化合物4-7对人类致病酵母白色念珠菌、光滑念珠菌和热带念珠菌表现出抗真菌活性，其最低抑菌浓度值在12.5至100微克/毫升之间。
