来自短柱菝葜的生物活性甾体皂苷。
Bioactive steroidal saponins from Smilax medica.
作者信息
Sautour M, Miyamoto T, Lacaille-Dubois M-A
机构信息
Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB, UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
出版信息
Planta Med. 2006 Jun;72(7):667-70. doi: 10.1055/s-2006-931582. Epub 2006 May 29.
Two new spirostanol saponins ( 1 and 2) were isolated from the roots of Smilax medica, together with the known smilagenin 3-O-beta-D-glucopyranoside (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR experiments. Compounds 1 and 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs between 6.25 and 50 microg/mL) whereas 3 was inactive.
从短柱菝葜根部分离出两种新的螺旋甾烷醇皂苷（1和2），以及已知的薯蓣皂苷元3 - O - β - D - 吡喃葡萄糖苷（3）。通过包括一维和二维核磁共振实验在内的光谱方法确定了它们的结构。化合物1和2对人类致病酵母白色念珠菌、光滑念珠菌和热带念珠菌表现出抗真菌活性（最低抑菌浓度在6.25至50微克/毫升之间），而化合物3无活性。
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