Volchegorskiĭ I A, Val'dman B M, Skobeleva N A, Tseĭlikman V E, Lifshits R I
Patol Fiziol Eksp Ter. 1991 May-Jun(3):44-7.
Fractions of medium-weight molecular peptides (MWP) were isolated from blood of intact dogs and those with burns, which possessed the property of increasing the latency of the pain reaction in mice by 23-28% after intravenous infusion. The analgesic properties of MWP change essentially in the first 24 hours after the burn. The dose dependences of the antinociceptive effect of MWP have a marked non-linear character. The studied MWP fractions also prevent involution of the thymus induced by 9-hour immobilization stress. An MWP fraction was isolated from the blood of dogs 12 hours after a burn; its intravenous infusion led to reduction of the thymus equal to that caused by 9-hour immobilization. The relationship of adaptational and damaging effects of MWP in thermal burns in discussed.
从中等体重分子肽（MWP）的组分是从完整犬和烧伤犬的血液中分离得到的，静脉输注后这些组分具有使小鼠疼痛反应潜伏期延长23%-28%的特性。MWP的镇痛特性在烧伤后的最初24小时内基本发生变化。MWP的抗伤害感受作用的剂量依赖性具有明显的非线性特征。所研究的MWP组分还可防止由9小时固定应激诱导的胸腺退化。从烧伤后12小时的犬血液中分离出一种MWP组分；其静脉输注导致胸腺缩小，程度与9小时固定所引起的相同。文中讨论了MWP在热烧伤中的适应性和损伤性作用的关系。
