Dürrigl T, Vitaus M, Pucar I, Miko M
Institute for Rehabilitation of Rheumatic Patients, Medical Faculty, University of Zagreb, Yugoslavia.
J Int Med Res. 1975;3(3):139-44. doi: 10.1177/030006057500300301.
A short-term trial has been performed under double-blind conditions in 50 adult patients with rheumatoid arthritis to compare diclofenac sodium (Voltaren) with both indomethacin and placebo for efficacy and tolerability. The duration of the trial was two weeks and was a between-patient comparison of 25 mg t.i.d. diclofenac sodium, 25 mg t.i.d. indomethacin or placebo using a double-dummy technique. Forty-eight patients completed the trial. In the majority of parameters examined, diclofenac sodium was superior to placebo and indomethacin in therapeutic effect. One patient was withdrawn from the trial because of intolerance to indomethacin and one other because of severe joint pain under indomethacin therapy. Neither active compound caused clinically significant changes in blood picture or urine analysis.
在50名成年类风湿性关节炎患者中进行了一项双盲条件下的短期试验，以比较双氯芬酸钠（扶他林）与消炎痛及安慰剂在疗效和耐受性方面的差异。试验为期两周，采用双盲法对25毫克每日三次的双氯芬酸钠、25毫克每日三次的消炎痛或安慰剂进行患者间比较。48名患者完成了试验。在大多数检测参数中，双氯芬酸钠在治疗效果上优于安慰剂和消炎痛。一名患者因对消炎痛不耐受而退出试验，另一名患者因在消炎痛治疗下出现严重关节疼痛而退出。两种活性化合物均未引起血常规或尿液分析的临床显著变化。
