唾液免疫球蛋白A抗麦醇溶蛋白抗体作为乳糜泻的标志物
Salivary IgA antigliadin antibody as a marker for coeliac disease.
作者信息
Hakeem V, Fifield R, al-Bayaty H F, Aldred M J, Walker D M, Williams J, Jenkins H R
机构信息
Department of Child Health, Royal Infirmary, Cardiff.
出版信息
Arch Dis Child. 1992 Jun;67(6):724-7. doi: 10.1136/adc.67.6.724.
Abstract
In recent years, serum antibodies to gliadin (AGA) have been reported to be useful markers of coeliac disease. IgA AGA have also been found in intestinal secretions and saliva in coeliac disease and may offer a convenient, non-invasive screening test. In order to test this hypothesis, salivary and serum AGA were measured in children with coeliac disease proved by biopsy and compared with several control groups. Measurement of salivary IgA AGA provided excellent discrimination between those children with coeliac disease and the control groups, and our study suggests that it may provide a rapid, non-invasive method of screening for this disease before intestinal biopsy.
摘要
近年来，抗麦醇溶蛋白血清抗体（AGA）已被报道为乳糜泻的有用标志物。在乳糜泻患者的肠道分泌物和唾液中也发现了IgA AGA，这可能提供一种方便、非侵入性的筛查测试。为了验证这一假设，对经活检证实患有乳糜泻的儿童进行了唾液和血清AGA检测，并与几个对照组进行了比较。唾液IgA AGA检测能够很好地区分患有乳糜泻的儿童和对照组，我们的研究表明，它可能提供一种在肠道活检前快速、非侵入性的该疾病筛查方法。
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本文引用的文献
1
Serum gliadin antibodies for detection and control of childhood coeliac disease.用于儿童乳糜泻检测与控制的血清麦醇溶蛋白抗体
Acta Paediatr Scand. 1984 Sep;73(5):657-63. doi: 10.1111/j.1651-2227.1984.tb09991.x.
2
IgA anti-endomysium antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease.IgA抗肌内膜抗体。疱疹样皮炎和乳糜泻的一种新的免疫学标志物。
Br J Dermatol. 1984 Oct;111(4):395-402. doi: 10.1111/j.1365-2133.1984.tb06601.x.
3
Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children.乳糜泻患儿血清和上消化道分泌物中针对膳食蛋白质的沉淀素
Br Med J. 1972 Jan 8;1(5792):75-7. doi: 10.1136/bmj.1.5792.75.
4
Serum IgA and IgG gliadin antibodies and small intestinal mucosal damage in children.儿童血清IgA和IgG麦醇溶蛋白抗体与小肠黏膜损伤
J Pediatr Gastroenterol Nutr. 1985 Dec;4(6):917-22. doi: 10.1097/00005176-198512000-00011.
5
Secretion of gliadin antibody by coeliac jejunal mucosal biopsies cultured in vitro.体外培养的乳糜泻空肠黏膜活检组织分泌麦醇溶蛋白抗体。
Clin Exp Immunol. 1986 Apr;64(1):119-24.
6
Anti-reticulin antibodies: a diagnostic and monitoring test for childhood coeliac disease.抗网硬蛋白抗体：儿童乳糜泻的诊断与监测检测
Scand J Gastroenterol. 1986 Oct;21(8):955-7. doi: 10.3109/00365528608996402.
7
Antigliadin antibodies detected by enzyme-linked immunosorbent assay as a marker of childhood celiac disease.通过酶联免疫吸附测定法检测抗麦醇溶蛋白抗体作为儿童乳糜泻的标志物。
J Pediatr. 1988 Aug;113(2):286-9. doi: 10.1016/s0022-3476(88)80266-x.
8
The common mucosal immune system and current strategies for induction of immune responses in external secretions.共同黏膜免疫系统及在外分泌液中诱导免疫反应的当前策略。
J Clin Immunol. 1987 Jul;7(4):265-76. doi: 10.1007/BF00915547.
9
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J Pediatr Gastroenterol Nutr. 1988 Nov-Dec;7(6):858-63. doi: 10.1097/00005176-198811000-00011.
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