Hakeem V, Fifield R, al-Bayaty H F, Aldred M J, Walker D M, Williams J, Jenkins H R
Department of Child Health, Royal Infirmary, Cardiff.
Arch Dis Child. 1992 Jun;67(6):724-7. doi: 10.1136/adc.67.6.724.
In recent years, serum antibodies to gliadin (AGA) have been reported to be useful markers of coeliac disease. IgA AGA have also been found in intestinal secretions and saliva in coeliac disease and may offer a convenient, non-invasive screening test. In order to test this hypothesis, salivary and serum AGA were measured in children with coeliac disease proved by biopsy and compared with several control groups. Measurement of salivary IgA AGA provided excellent discrimination between those children with coeliac disease and the control groups, and our study suggests that it may provide a rapid, non-invasive method of screening for this disease before intestinal biopsy.
近年来，抗麦醇溶蛋白血清抗体（AGA）已被报道为乳糜泻的有用标志物。在乳糜泻患者的肠道分泌物和唾液中也发现了IgA AGA，这可能提供一种方便、非侵入性的筛查测试。为了验证这一假设，对经活检证实患有乳糜泻的儿童进行了唾液和血清AGA检测，并与几个对照组进行了比较。唾液IgA AGA检测能够很好地区分患有乳糜泻的儿童和对照组，我们的研究表明，它可能提供一种在肠道活检前快速、非侵入性的该疾病筛查方法。
