Seifi Tahereh, Reza Kamali Ali
Energy and Environmental Materials Research Centre (E2MC), School of Metallurgy, Northeastern University, Shenyang 110819, China.
Med Drug Discov. 2021 Sep;11:100099. doi: 10.1016/j.medidd.2021.100099. Epub 2021 May 25.
Coronavirus disease-2019 has been one of the most challenging global epidemics of modern times with a large number of casualties combined with economic hardships across the world. Considering that there is still no definitive cure for the recent viral crisis, this article provides a review of nanomaterials with antiviral activity, with an emphasis on graphene and its derivatives, including graphene oxide, reduced graphene oxide and graphene quantum dots. The possible interactions between surfaces of such nanostructured materials with coronaviruses are discussed. The antiviral mechanisms of graphene materials can be related to events such as the inactivation of virus and/or the host cell receptor, electrostatic trapping and physico-chemical destruction of viral species. These effects can be enhanced by functionalization and/or decoration of carbons with species that enhances graphene-virus interactions. The low-cost and large-scale preparation of graphene materials with enhanced antiviral performances is an interesting research direction to be explored.
2019冠状病毒病是现代最具挑战性的全球流行病之一,造成了大量人员伤亡,并给全球带来了经济困难。鉴于目前仍没有针对这一近期病毒危机的确切治愈方法,本文综述了具有抗病毒活性的纳米材料,重点介绍了石墨烯及其衍生物,包括氧化石墨烯、还原氧化石墨烯和石墨烯量子点。讨论了此类纳米结构材料表面与冠状病毒之间可能的相互作用。石墨烯材料的抗病毒机制可能与病毒和/或宿主细胞受体的失活、静电捕获以及病毒物种的物理化学破坏等事件有关。通过用增强石墨烯与病毒相互作用的物质对碳进行功能化和/或修饰,可以增强这些效果。探索低成本、大规模制备具有增强抗病毒性能的石墨烯材料是一个有趣的研究方向。