Yuste Rafael
Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027.
Neuron. 2005 Nov 23;48(4):524-7. doi: 10.1016/j.neuron.2005.11.012.
Neocortical interneurons are very diverse in morphological, physiological, molecular, and developmental characteristics. Recent work is discovering strong correlations between these phenotypic features, confirming the intuition of Cajal and Lorente that distinct classes of interneurons exist, each presumably mediating a different circuit function. A paper by Butt et al. in this issue of Neuron describes correlations between the developmental origin of interneurons and their anatomical, electrophysiological, and molecular properties. An effort to standardize the nomenclature of interneurons is underway. Because different interneuron subtypes have different ontogenic origin, they could be classified based on their developmental specification by transcription factors.
新皮层中间神经元在形态、生理、分子和发育特征方面具有很大的多样性。最近的研究发现这些表型特征之间存在着紧密的关联，证实了 Cajal 和 Lorente 的直觉，即存在不同类别的中间神经元，每一类可能介导不同的回路功能。Butt 等人在本期《神经元》杂志上发表的一篇论文描述了中间神经元的发育起源与其解剖学、电生理学和分子特性之间的关联。目前正在努力规范中间神经元的命名法。由于不同的中间神经元亚型具有不同的个体发生起源，因此可以根据转录因子对它们的发育规范进行分类。
