哥伦比亚肺炎克雷伯菌中分离出的新型 VIM 金属β-内酰胺酶变体 VIM-24。
Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.
机构信息
International Center for Medical Research and Training (CIDEIM), Carrera 125 # 19-225, Cali, Colombia.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2428-30. doi: 10.1128/AAC.01208-10. Epub 2011 Jan 31.
Abstract
We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located within a class 1 integron carried on a large plasmid. Further studies are needed to clarify its epidemiological and clinical impact.
摘要
我们报告了在哥伦比亚分离的肺炎克雷伯菌中出现了一种新型 VIM 变体（VIM-24）。该分离株对碳青霉烯类药物的 MIC 值低于耐药临界点，这对其检测构成了真正的挑战。blaVIM-24 基因位于一个大质粒上的 1 类整合子内。需要进一步研究来阐明其流行病学和临床影响。
相似文献
1
Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.
Antimicrob Agents Chemother. 2011 May;55(5):2428-30. doi: 10.1128/AAC.01208-10. Epub 2011 Jan 31.
2
Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.
Antimicrob Agents Chemother. 2011 Jul;55(7):3570-2. doi: 10.1128/AAC.00238-11. Epub 2011 Apr 25.
3
Ongoing epidemic of blaVIM-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey.
J Antimicrob Chemother. 2008 Jan;61(1):59-63. doi: 10.1093/jac/dkm443. Epub 2007 Nov 13.
4
Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.
Antimicrob Agents Chemother. 2009 Dec;53(12):5046-54. doi: 10.1128/AAC.00774-09. Epub 2009 Sep 21.
5
Emergence of Multidrug-Resistant New Delhi Metallo-β-Lactamase-1-Producing Klebsiella pneumoniae in Egypt.
Microb Drug Resist. 2017 Jun;23(4):480-487. doi: 10.1089/mdr.2016.0003. Epub 2016 Aug 30.
6
VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.
Antimicrob Agents Chemother. 2005 Dec;49(12):5153-6. doi: 10.1128/AAC.49.12.5153-5156.2005.
7
First detection of a carbapenem-hydrolyzing metalloenzyme in two enterobacteriaceae isolates in Spain.
Antimicrob Agents Chemother. 2005 Aug;49(8):3492-4. doi: 10.1128/AAC.49.8.3492-3494.2005.
8
VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2010 Jan;54(1):471-6. doi: 10.1128/AAC.00458-09. Epub 2009 Nov 16.
9
Sources of diversity of carbapenem resistance levels in Klebsiella pneumoniae carrying blaVIM-1.
J Antimicrob Chemother. 2006 Sep;58(3):669-72. doi: 10.1093/jac/dkl302. Epub 2006 Jul 26.
10
Molecular characterization of carbapenem-resistant strains of Klebsiella pneumoniae isolated from Iranian patients: first identification of blaKPC gene in Iran.
Microb Drug Resist. 2014 Aug;20(4):285-93. doi: 10.1089/mdr.2013.0074. Epub 2014 Jan 15.
引用本文的文献
1
ST471 Producing VIM-4 Metallo-β-Lactamase in Colombia.
Microb Drug Resist. 2022 Mar;28(3):288-292. doi: 10.1089/mdr.2021.0031. Epub 2022 Jan 4.
2
Complexity of Genomic Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolates in Colombia Urges the Reinforcement of Whole Genome Sequencing-Based Surveillance Programs.
Clin Infect Dis. 2021 Dec 1;73(Suppl_4):S290-S299. doi: 10.1093/cid/ciab777.
3
Molecular Characterization of KPC-2-Producing Complex Isolates from Cali, Colombia.
Antibiotics (Basel). 2021 Jun 10;10(6):694. doi: 10.3390/antibiotics10060694.
4
Bogotá River anthropogenic contamination alters microbial communities and promotes spread of antibiotic resistance genes.
Sci Rep. 2019 Aug 13;9(1):11764. doi: 10.1038/s41598-019-48200-6.
5
A Novel VIM-Type Metallo-β-Lactamase Variant, VIM-60, with Increased Hydrolyzing Activity against Fourth-Generation Cephalosporins in Pseudomonas aeruginosa Clinical Isolates in Japan.
Antimicrob Agents Chemother. 2019 May 24;63(6). doi: 10.1128/AAC.00124-19. Print 2019 Jun.
6
Genetic Characterization of a -Carrying IncP-7β Plasmid p1160-VIM and a -Harboring Integrative and Conjugative Element Tn From Clinical .
Front Microbiol. 2019 Feb 26;10:213. doi: 10.3389/fmicb.2019.00213. eCollection 2019.
7
A cluster of KPC-2 and VIM-2-producing Klebsiella pneumoniae ST833 isolates from the pediatric service of a Venezuelan Hospital.
BMC Infect Dis. 2016 Oct 22;16(1):595. doi: 10.1186/s12879-016-1927-y.
8
Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases.
Biochemistry. 2015 May 26;54(20):3183-96. doi: 10.1021/acs.biochem.5b00106. Epub 2015 May 12.
9
Emergence of Klebsiella pneumoniae Coharboring KPC and VIM Carbapenemases in Colombia.
Antimicrob Agents Chemother. 2013 Feb;57(2):1101-2. doi: 10.1128/AAC.01666-12. Epub 2012 Dec 10.
本文引用的文献
1
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study.
Lancet Infect Dis. 2010 Sep;10(9):597-602. doi: 10.1016/S1473-3099(10)70143-2. Epub 2010 Aug 10.
2
Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria.
Antimicrob Agents Chemother. 2010 Jan;54(1):466-70. doi: 10.1128/AAC.00017-09. Epub 2009 Nov 9.
3
First isolation of a VIM-producing Klebsiella pneumoniae from a seven-year-old child in Venezuela.
J Infect Dev Ctries. 2008 Jun 1;2(3):241-4. doi: 10.3855/jidc.270.
4
Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases.
Antimicrob Agents Chemother. 2009 Sep;53(9):4048-50. doi: 10.1128/AAC.00690-09. Epub 2009 Jul 6.
5
Dissemination of a bla(VIM-2)-carrying integron among Enterobacteriaceae species in Mexico: report from the SENTRY Antimicrobial Surveillance Program.
Microb Drug Resist. 2009 Mar;15(1):33-5. doi: 10.1089/mdr.2009.0878.
6
High rates of metallo-beta-lactamase-producing Klebsiella pneumoniae in Greece--a review of the current evidence.
Euro Surveill. 2008 Jan 24;13(4):8023.
7
Carbapenemases: the versatile beta-lactamases.
Clin Microbiol Rev. 2007 Jul;20(3):440-58, table of contents. doi: 10.1128/CMR.00001-07.
8
Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues.
Int J Antimicrob Agents. 2007 Apr;29(4):380-8. doi: 10.1016/j.ijantimicag.2006.10.008. Epub 2007 Jan 16.
9
Emergence of multidrug-resistant Klebsiella pneumoniae isolates producing VIM-4 metallo-beta-lactamase, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC beta-lactamase in a Tunisian university hospital.
Antimicrob Agents Chemother. 2006 Dec;50(12):4198-201. doi: 10.1128/AAC.00663-06. Epub 2006 Oct 2.
10
First detection of metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa isolates from Colombia.
Antimicrob Agents Chemother. 2006 Jan;50(1):226-9. doi: 10.1128/AAC.50.1.226-229.2006.
Zotero 插件