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哥伦比亚肺炎克雷伯菌中分离出的新型 VIM 金属β-内酰胺酶变体 VIM-24。

Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.

机构信息

International Center for Medical Research and Training (CIDEIM), Carrera 125 # 19-225, Cali, Colombia.

出版信息

Antimicrob Agents Chemother. 2011 May;55(5):2428-30. doi: 10.1128/AAC.01208-10. Epub 2011 Jan 31.

DOI:10.1128/AAC.01208-10
PMID:21282438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3088182/
Abstract

We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located within a class 1 integron carried on a large plasmid. Further studies are needed to clarify its epidemiological and clinical impact.

摘要

我们报告了在哥伦比亚分离的肺炎克雷伯菌中出现了一种新型 VIM 变体（VIM-24）。该分离株对碳青霉烯类药物的 MIC 值低于耐药临界点，这对其检测构成了真正的挑战。blaVIM-24 基因位于一个大质粒上的 1 类整合子内。需要进一步研究来阐明其流行病学和临床影响。

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