Lekakis John, Rallidis Loukianos S, Andreadou Ioanna, Vamvakou Georgia, Kazantzoglou Georgios, Magiatis Prokopios, Skaltsounis Alexios-Leandros, Kremastinos Dimitrios T
Second Department of Cardiology, University General Hospital, Attikon, Greece.
Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600. doi: 10.1097/00149831-200512000-00013.
It has been shown that acute intake of red wine improves endothelial-dependent vasodilatation. It is not clear, however, which constituents of red wine are responsible for this effect. We examined whether acute intake of a red grape polyphenol extract has a positive effect on brachial artery flow-mediated dilatation.
We recruited 30 male patients with coronary heart disease. They were randomly assigned either to a red grape polyphenol extract (600 mg) dissolved in 20 ml of water (n = 15) or 20 ml of water (placebo) (n = 15). The extract of grapes contained 4.32 mg epicatechin, 2.72 mg catechin, 2.07 mg gallic acid, 0.9 mg trans-resveratrol, 0.47 mg rutin, 0.42 mg epsilon-viniferin, 0.28 mg, p-coumaric acid, 0.14 mg ferulic acid and 0.04 mg quercetin per gram. Flow-mediated dilatation of the brachial artery was evaluated after reactive hyperemia induced by cuff obstruction of the forearm, using high-resolution ultasonography. Particularly, flow-mediated dilatation was measured after fasting and 30, 60 and 120 min after the intake of the grape extract or placebo.
Intake of the red grape polyphenol extract caused an increase in flow-mediated dilatation, peaking at 60 min, which was significantly higher than the baseline values (4.52+/-1.34 versus 2.6+/-1.5%; P < 0.001) and the corresponding values at 60 min after the intake of placebo (4.52+/-1.34 versus 2.64+/-1.8%, P < 0.001). There was no change in FMD values after the intake of placebo throughout the whole duration of the study.
Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. These results could probably, at least partly, explain the favorable effects of red wine on the cardiovascular system.
研究表明，急性摄入红酒可改善内皮依赖性血管舒张功能。然而，红酒中哪些成分导致了这种作用尚不清楚。我们研究了急性摄入红葡萄多酚提取物是否对肱动脉血流介导的舒张功能有积极影响。
我们招募了30名男性冠心病患者。他们被随机分为两组，一组饮用溶解于20毫升水中的红葡萄多酚提取物（600毫克）（n = 15），另一组饮用20毫升水（安慰剂）（n = 15）。每克葡萄提取物含有4.32毫克表儿茶素、2.72毫克儿茶素、2.07毫克没食子酸、0.9毫克反式白藜芦醇、0.47毫克芦丁、0.42毫克ε-葡萄素、0.28毫克对香豆酸、0.14毫克阿魏酸和0.04毫克槲皮素。在前臂袖带阻断诱导反应性充血后，使用高分辨率超声评估肱动脉的血流介导舒张功能。具体而言，在空腹以及摄入葡萄提取物或安慰剂后30、60和120分钟测量血流介导舒张功能。
摄入红葡萄多酚提取物导致血流介导舒张功能增加，在60分钟时达到峰值，显著高于基线值（4.52±1.34对2.6±1.5%；P < 0.001）以及摄入安慰剂后60分钟时的相应值（4.52±1.34对2.64±1.8%，P < 0.001）。在整个研究期间，摄入安慰剂后FMD值没有变化。
红葡萄中的多酚化合物可急性改善冠心病患者的内皮功能。这些结果可能至少部分解释了红酒对心血管系统的有益作用。
