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来自红树林放线菌的天然产物。

Natural products from mangrove actinomycetes.

作者信息

Xu Dong-Bo, Ye Wan-Wan, Han Ying, Deng Zi-Xin, Hong Kui

机构信息

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.

出版信息

Mar Drugs. 2014 May 2;12(5):2590-613. doi: 10.3390/md12052590.

DOI:10.3390/md12052590
PMID:24798926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4052306/
Abstract

Mangroves are woody plants located in tropical and subtropical intertidal coastal regions. The mangrove ecosystem is becoming a hot spot for natural product discovery and bioactivity survey. Diverse mangrove actinomycetes as promising and productive sources are worth being explored and uncovered. At the time of writing, we report 73 novel compounds and 49 known compounds isolated from mangrove actinomycetes including alkaloids, benzene derivatives, cyclopentenone derivatives, dilactones, macrolides, 2-pyranones and sesquiterpenes. Attractive structures such as salinosporamides, xiamycins and novel indolocarbazoles are highlighted. Many exciting compounds have been proven as potential new antibiotics, antitumor and antiviral agents, anti-fibrotic agents and antioxidants. Furthermore, some of their biosynthetic pathways have also been revealed. This review is an attempt to consolidate and summarize the past and the latest studies on mangrove actinomycetes natural product discovery and to draw attention to their immense potential as novel and bioactive compounds for marine drugs discovery.

摘要

红树林是生长在热带和亚热带潮间带沿海地区的木本植物。红树林生态系统正成为天然产物发现和生物活性研究的热点。多样的红树林放线菌作为有前景且多产的来源，值得去探索和发现。在撰写本文时，我们报道了从红树林放线菌中分离出的73种新化合物和49种已知化合物，包括生物碱、苯衍生物、环戊烯酮衍生物、双内酯、大环内酯、2-吡喃酮和倍半萜。突出了如盐孢霉素、夏霉素和新型吲哚咔唑等具有吸引力的结构。许多令人兴奋的化合物已被证明是潜在的新型抗生素、抗肿瘤和抗病毒药物、抗纤维化药物和抗氧化剂。此外，还揭示了它们的一些生物合成途径。这篇综述旨在整合和总结过去及最新关于红树林放线菌天然产物发现的研究，并提请人们注意它们作为发现海洋药物的新型生物活性化合物的巨大潜力。

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