Stoeck Katharina, Bodemer Monika, Zerr Inga
Department of Neurology, University of Göttingen, Robert-Koch Str.40, 37075 Göttingen, Germany.
J Neuroimmunol. 2006 Mar;172(1-2):175-81. doi: 10.1016/j.jneuroim.2005.10.008. Epub 2005 Dec 2.
We investigated cerebrospinal fluid (CSF) samples from patients with Creutzfeldt-Jakob disease (CJD) and other neurological diseases. Concentrations of pro- and anti-inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha and TGF-beta 2 were determined in CSF using ELISA. Significant changes were found for IL-8 and TGF-beta 2. IL-8 levels were elevated in the CSF of CJD patients. Of interest, the increase was significant to other dementia and to controls. In contrast, TGF-beta 2 was significantly decreased in CSF of CJD compared to all groups. IL-1beta, IL-12 and TNF-alpha could not be detected in CSF or in case of IL-6 in only low concentrations without significant difference.
我们研究了克雅氏病（CJD）患者及其他神经系统疾病患者的脑脊液（CSF）样本。使用酶联免疫吸附测定法（ELISA）测定了CSF中促炎和抗炎细胞因子白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-12（IL-12）、肿瘤坏死因子-α（TNF-α）和转化生长因子-β2（TGF-β2）的浓度。发现IL-8和TGF-β2有显著变化。CJD患者CSF中的IL-8水平升高。有趣的是，与其他痴呆症患者和对照组相比，这种升高具有显著性。相比之下，与所有组相比，CJD患者CSF中的TGF-β2显著降低。在CSF中未检测到IL-1β、IL-12和TNF-α，或者仅检测到低浓度的IL-6，且无显著差异。
