Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
BMC Neurol. 2023 Jan 23;23(1):34. doi: 10.1186/s12883-023-03076-y.
Creutzfeldt-Jakob disease (CJD) is a fatal and irreversible neurodegenerative disease. Identification of inexpensive and easy-to-implement biomarkers of CJD which could predict disease severity and patient survival is important for improving disease management. The aim of this study was to assess the predictive value of peripheral neutrophil to lymphocyte ratio (NLR), high-density lipoprotein (HDL), monocyte to HDL ratio (MHR) and neutrophil to HDL ratio (NHR) for CJD.
Patients with definite or probable CJD admitted to the Neurology Department of Xuanwu Hospital from 2014 to 2021 were enrolled and followed up until April 2022. Clinical information including sex, age, Barth Index, survival time and results of auxiliary examination were collected, and NLR, HDL, NHR and MHR were measured for all enrolled patients. The associations between NLR, HDL, NHR and MHR, and disease severity (evaluated by Barth Index), survival time and auxiliary examinations were evaluated.
A total of 88 CJD patients were enrolled and all were deceased. NLR (r = -0.341, p = 0.001), NHR (r = -0.346, p = 0.001) and MHR (r = -0.327, p = 0.002) were significantly associated with disease severity. Higher NHR (HR = 2.344, 95% CI = 1.277-4.303 p = 0.006) and lower HDL (HR = 0.567, 95% CI = 0.346-0.930, p = 0.025) were associated with shorter survival time in the CJD patients.
Peripheral inflammatory biomarkers, especially NHR, were associated with disease severity and survival duration. These findings provide new insights into the mechanisms and treatment strategies of CJD.
克雅氏病（CJD）是一种致命且不可逆转的神经退行性疾病。寻找廉价且易于实施的 CJD 生物标志物来预测疾病严重程度和患者生存情况，对于改善疾病管理非常重要。本研究旨在评估外周血中性粒细胞与淋巴细胞比值（NLR）、高密度脂蛋白（HDL）、单核细胞与 HDL 比值（MHR）和中性粒细胞与 HDL 比值（NHR）对 CJD 的预测价值。
本研究纳入了 2014 年至 2021 年期间宣武医院神经内科收治的确诊或疑似 CJD 患者，并进行了随访，随访时间截至 2022 年 4 月。收集了所有患者的临床信息，包括性别、年龄、Barth 指数、生存时间和辅助检查结果，并测量了 NLR、HDL、NHR 和 MHR。评估了 NLR、HDL、NHR 和 MHR 与疾病严重程度（Barth 指数评估）、生存时间和辅助检查的相关性。
共纳入 88 例 CJD 患者，均已死亡。NLR（r=-0.341，p=0.001）、NHR（r=-0.346，p=0.001）和 MHR（r=-0.327，p=0.002）与疾病严重程度显著相关。较高的 NHR（HR=2.344，95%CI=1.277-4.303，p=0.006）和较低的 HDL（HR=0.567，95%CI=0.346-0.930，p=0.025）与 CJD 患者的生存时间较短相关。
外周炎症生物标志物，尤其是 NHR，与疾病严重程度和生存时间相关。这些发现为 CJD 的发病机制和治疗策略提供了新的思路。
