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坦桑尼亚一个农村地区的氯喹自我药疗:对该国未来任何疟疾治疗政策变化而言都是一项治疗挑战。

Self-medication with chloroquine in a rural district of Tanzania: a therapeutic challenge for any future malaria treatment policy change in the country.

作者信息

Nsimba S E D, Rimoy G H

机构信息

Department of Clinical Pharmacology, Muhimbili University College of Health Sciences, MUCHS, Dar-es-Salaam, Tanzania.

出版信息

J Clin Pharm Ther. 2005 Dec;30(6):515-9. doi: 10.1111/j.1365-2710.2005.00645.x.

DOI:10.1111/j.1365-2710.2005.00645.x
PMID:16336283
Abstract

BACKGROUND

Malaria continues to be a leading cause of morbidity and mortality in children aged 5 years or younger in Tanzania. Children who develop mild disease can rapidly progress to severe malaria (cerebral malaria with convulsions) and even death, because of mismanagement, delays and inappropriate drug therapy in the remote areas where primary health care facilities are inaccessible or unavailable. The threat is particularly severe in those who are unable to take oral medications.

OBJECTIVE

To identify treatment strategies adopted by mothers or guardians of children under five for malaria.

METHOD

A cross-sectional descriptive study using a questionnaire and blood sampling was carried in Kibaha district primary health care facilities. Over 500 mothers/guardians of sick children aged up to 5 years who visited the public facilities seeking care were interviewed in order to assess what management they offered to their sick children in their homes prior to coming to the public health facilities.

RESULTS

Seventy-four per cent of the mothers/guardians stated that they had given some medication to their children prior to visiting the public health facilities: mostly analgesics (asprin, paracetamol) and chloroquine. Eighty-five per cent of the sick children given chloroquine had whole blood chloroquine levels above 500 nmol/L and 33% of the sick children with whole blood chloroquine levels above 1,000 nmol/L had malaria parasites in their blood. Of the sick children given chloroquine at the health facilities, 63% had no malaria parasites in their blood.

CONCLUSION

There is a need to educate both rural communities, and health care providers about rational prescribing, dispensing and use of antimalarials.

摘要

背景

疟疾仍然是坦桑尼亚5岁及以下儿童发病和死亡的主要原因。由于在偏远地区无法获得或没有初级卫生保健设施,管理不善、延误治疗和药物治疗不当,患轻度疾病的儿童可能会迅速发展为严重疟疾(伴有惊厥的脑型疟疾)甚至死亡。这种威胁在那些无法口服药物的儿童中尤为严重。

目的

确定5岁以下儿童的母亲或监护人针对疟疾所采用的治疗策略。

方法

在基巴哈区的初级卫生保健机构开展了一项采用问卷调查和血液采样的横断面描述性研究。对500多名到公共设施寻求治疗的5岁及以下患病儿童的母亲/监护人进行了访谈,以评估她们在带患病儿童前往公共卫生设施之前在家中对其采取了何种治疗措施。

结果

74%的母亲/监护人表示,在带孩子前往公共卫生设施之前,她们已给孩子服用了一些药物:主要是镇痛药(阿司匹林、对乙酰氨基酚)和氯喹。服用氯喹的患病儿童中,85%的全血氯喹水平高于500 nmol/L,全血氯喹水平高于1000 nmol/L的患病儿童中,33%的血液中有疟原虫。在卫生机构服用氯喹的患病儿童中,63%的血液中没有疟原虫。

结论

有必要对农村社区和卫生保健提供者进行关于合理开处方及配药和使用抗疟药方面的教育。

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