Trainor Mary T, Ridgway Peter, Macbeth Ron W, Wilday A Jill, Balmforth Helen F
Health & Safety Laboratory, Harpur Hill, Buxton, Derbyshire, UK.
J Hazard Mater. 2006 May 20;133(1-3):16-23. doi: 10.1016/j.jhazmat.2005.08.051. Epub 2005 Dec 9.
The aim of the EU Acute Exposure project, ACUTEX, is to develop a methodology for establishing European Acute Exposure Threshold Levels, EU AETLs, for toxic substances in relation to harm to people by inhalation. The development of AETLs is initially in the context of the risks of major accidents from chemical sites and in particular their regulation through the EU 'Seveso II' Directive. It is intended that AETLs can be used within Member States, where appropriate, to inform decisions on land-use planning and emergency planning. AETLs will not have a regulatory status. This paper describes: the selection of 21 preliminary substances to use as case studies in the development and testing of the AETL's methodology; and the development of a prioritisation methodology to inform initial substance selection for a possible further AETLs program. The work was based on consultation with experts drawn from EU major stakeholder groups. It included a Validation Exercise working with three Member States, which account for between approximately 40% and 50% of all EU Seveso II sites. From this Validation Exercise we infer that, if these three Member States are representative in terms of numbers of priority substances, then the number of EU higher priority substances for further AETLs development is unlikely to be much in excess of 50.
欧盟急性暴露项目（ACUTEX）的目标是制定一种方法，以确定与吸入性有害物质对人体造成的伤害相关的欧洲急性暴露阈值水平（EU AETLs）。AETLs的制定最初是针对化工场所重大事故的风险，特别是依据欧盟《塞韦索二号指令》对其进行的监管。旨在成员国在适当情况下可使用AETLs，为土地利用规划和应急规划决策提供参考。AETLs不具有监管地位。本文介绍了：选择21种初步物质作为AETL方法开发和测试的案例研究；以及开发一种优先级排序方法，为可能的进一步AETLs计划的初始物质选择提供参考。这项工作基于与欧盟主要利益相关者群体的专家进行的磋商。其中包括与三个成员国合作开展的验证活动，这三个成员国的塞韦索二号场所数量约占欧盟所有此类场所的40%至50%。从这次验证活动中我们推断，如果这三个成员国在优先物质数量方面具有代表性，那么进一步开展AETLs开发所需研究的欧盟高优先级物质数量不太可能大大超过50种。
