Ersoy Yasemin, Sonmez Emine, Tevfik Mehmet R, But Aype Dinç
Department of Infectious Diseases & Clinical Microbiology, Inonu University, Turgut Ozal Medical Centre, 44280 Malatya, Turkey.
Trop Doct. 2005 Oct;35(4):210-2. doi: 10.1258/004947505774938765.
The efficacy and tolerability of three different combination treatment regimens in human brucellosis were compared in 118 uncomplicated patients enrolled in a prospective study between May 1997 and December 2002. Brucellosis was diagnosed using standard clinical and microbiological findings. Patients with central nervous system involvement, spondylitis, endocarditis or children under 16 years of age were excluded from the study. Patients were randomly assigned to receive 400 mg of ofloxacin plus 600 mg of rifampicin (OR, n = 41), 200 mg of doxycycline plus 600 mg of rifampicin (DR, n = 45) or 1g intramuscularly streptomycin (administered for three weeks) plus 200 mg doxycycline (DS, n = 32) daily for 6 weeks. All patients were followed up at least 6 months after cessation of therapy. There was no statistical difference between the groups on relapse rates and clinical response to the treatment (P>0.05). Five patients in OR (12.8%), six patients in DR (14.3%) and three patients in DS groups (9.7%) suffered relapse. The side-effects were seen in eight (19.5%), 21 (46.7%) and eight (25.0%) patients of OR, DR and DS groups, respectively. The use of combination therapy of ofloxacin plus rifampicin for 6 weeks was found to be as effective as DR and DS. The side-effects of therapy in OR and DS groups was less severe than in the DR group.
1997年5月至2002年12月期间，一项前瞻性研究纳入了118例非复杂性布鲁氏菌病患者，比较了三种不同联合治疗方案的疗效和耐受性。布鲁氏菌病根据标准临床和微生物学检查结果进行诊断。中枢神经系统受累、脊柱炎、心内膜炎患者或16岁以下儿童被排除在研究之外。患者被随机分配接受400毫克氧氟沙星加600毫克利福平（OR组，n = 41）、200毫克强力霉素加600毫克利福平（DR组，n = 45）或每日1克肌肉注射链霉素（连用三周）加200毫克强力霉素（DS组，n = 32），疗程6周。所有患者在治疗结束后至少随访6个月。各组间复发率和治疗临床反应无统计学差异（P>0.05）。OR组5例（12.8%）、DR组6例（14.3%）和DS组3例（9.7%）出现复发。OR组、DR组和DS组分别有8例（19.5%）、21例（46.7%）和8例（25.0%）患者出现副作用。发现氧氟沙星加利福平联合治疗6周与DR组和DS组疗效相当。OR组和DS组治疗副作用比DR组轻。
