Molloy Cynthia A, Morrow Ardythe L, Meinzen-Derr Jareen, Schleifer Kathleen, Dienger Krista, Manning-Courtney Patricia, Altaye Mekibib, Wills-Karp Marsha
Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, United States.
J Neuroimmunol. 2006 Mar;172(1-2):198-205. doi: 10.1016/j.jneuroim.2005.11.007. Epub 2005 Dec 19.
This study compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-gamma/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10 than controls.
Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.
本研究比较了20名自闭症谱系障碍儿童外周血单个核细胞与匹配对照组外周血单个核细胞中白细胞介素-2（IL-2）、干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）、白细胞介素-13（IL-13）、白细胞介素-5（IL-5）和白细胞介素-10（IL-10）的产生情况。仅在培养基中孵育后，所有Th2细胞因子水平在病例组中显著更高，但病例组与对照组之间的IFN-γ/IL-13比值无显著差异。病例组的IL-13/IL-10和IFN-γ/IL-10显著高于对照组。
自闭症谱系障碍儿童适应性免疫反应的Th2和Th1分支均有激活增加，以Th2为主导，且调节性细胞因子IL-10无代偿性增加。
