Hsu Ping-Chi, Chen I-Yueh, Pan Chih-Hong, Wu Kuen-Yuh, Pan Min-Hsiung, Chen Jenq-Renn, Chen Cheng-Jung, Chang-Chien Guo-Ping, Hsu Chang-Hung, Liu Chiu-Shong, Wu Ming-Tsang
Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan.
Int Arch Occup Environ Health. 2006 May;79(5):349-56. doi: 10.1007/s00420-005-0066-3. Epub 2005 Dec 15.
The aim was to determine whether occupational exposure to polycyclic aromatic hydrocarbons (PAHs) in men has adverse effect on semen quality.
Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels, and parameters of semen quality were determined.
TO workers had significantly higher ambient PAHs exposure (3,436.1+/-3,411.0 vs. 1,123.1+/-1,829.3 ng/m3, P < 0.01), urinary 1-OHP levels (207.8+/-176.4 vs. 54.0+/-44.8 microg/g, P < 0.001), frequency of oligospermia (18.8 vs. 0%, P < 0.05), and morphological abnormality in sperm (32.3 vs. 14.6%, P < 0.01) than SO workers. Among cigarette smokers, TO workers had significantly higher rates of DNA denaturation in spermatozoa (alphaT) and percentage of sperm with increased DNA denaturation (COMP alphaT) levels than SO workers (246.2+/-49.5 vs. 198.1+/-30.3 for alphaT; 34.8+/-14.4 vs. 19.3+/-13.9% for COMP alphaT, P < 0.05). There was a positive correlation between urinary 1-OHP and alphaT, COMP alphaT, and abnormal sperm morphology and a tenfold increase in urinary 1-OHP associated with a 2.35-fold increase in alphaT, as well as a 1.07-fold increase in percentage of sperm with abnormal morphology.
A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction.
本研究旨在确定男性职业性接触多环芳烃（PAHs）是否会对精液质量产生不良影响。
对48名炼焦工人进行了研究，其中包括16名炉顶工（TO）和32名侧炉工（SO）。测定了环境PAHs暴露水平、尿中1-羟基芘（1-OHP）水平以及精液质量参数。
与SO工人相比，TO工人的环境PAHs暴露水平显著更高（3436.1±3411.0 vs. 1123.1±1829.3 ng/m3，P<0.01），尿1-OHP水平显著更高（207.8±176.4 vs. 54.0±44.8 μg/g，P<0.001），少精子症发生率显著更高（18.8% vs. 0%，P<0.05），精子形态异常率显著更高（32.3% vs. 14.6%，P<0.01）。在吸烟者中，TO工人精子DNA变性率（alphaT）和DNA变性增加的精子百分比（COMP alphaT）显著高于SO工人（alphaT：246.2±49.5 vs. 198.1±30.3；COMP alphaT：34.8±14.4% vs. 19.3±13.9%，P<0.05）。尿1-OHP与alphaT、COMP alphaT以及精子形态异常之间呈正相关，尿1-OHP增加10倍与alphaT增加2.35倍以及精子形态异常百分比增加1.07倍相关。
对于职业性接触高水平PAHs的工人，应考虑精子功能障碍的潜在风险。吸烟可能会加剧这种风险。尿1-OHP可作为预测精子功能障碍的生物标志物。
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