霍奇金病中里德-斯腾伯格细胞的波形蛋白表达。
Vimentin expression by Reed-Sternberg cells in Hodgkin's disease.
作者信息
Angel C A, Cullen R A, Pringle J H, Lauder I
机构信息
Department of Pathology, University of Sheffield Medical School, UK.
出版信息
Virchows Arch A Pathol Anat Histopathol. 1992;421(1):9-11. doi: 10.1007/BF01607132.
The expression of vimentin in Reed-Sternberg cells in 61 samples of Hodgkin's disease (HD) was examined using an avidin-biotin-peroxidase complex technique. Forty biopsies (66%) expressed vimentin, and expression was seen in all subtypes of HD. No immunophenotypic differences between vimentin-positive and vimentin-negative cases were noted. The significance of such expression is unclear, but may be related to the alterations in growth and differentiation that are typical of neoplastic cells.
采用抗生物素蛋白-生物素-过氧化物酶复合物技术检测了61例霍奇金淋巴瘤（HD）样本中里德-斯腾伯格细胞波形蛋白的表达情况。40例活检样本（66%）表达波形蛋白，且在HD的所有亚型中均可见该表达。波形蛋白阳性和阴性病例之间未发现免疫表型差异。这种表达的意义尚不清楚，但可能与肿瘤细胞典型的生长和分化改变有关。
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