新世界猴南希夜猴作为空肠弯曲菌感染与免疫的模型。
New World monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity.
作者信息
Jones Franca R, Baqar Shahida, Gozalo Alfonso, Nunez Gladys, Espinoza Nereyda, Reyes Sharina M, Salazar Milagros, Meza Rina, Porter Chad K, Walz Stephen E
机构信息
Naval Medical Research Center, Biological Defense Research Directorate, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
出版信息
Infect Immun. 2006 Jan;74(1):790-3. doi: 10.1128/IAI.74.1.790-793.2006.
Abstract
Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.
摘要
将三组，每组六只南希夜猴（Aotus nancymae）经胃内接种空肠弯曲菌，接种剂量逐渐增加。感染导致粪便定植（100%的猴子）、剂量相关的腹泻以及强烈的免疫反应。再次攻击后，定植持续时间和腹泻率降低。南希夜猴可能有助于研究抗弯曲菌疫苗的效力。
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