Babakhani F K, Bradley G A, Joens L A
Department of Veterinary Sciences, University of Arizona, Tucson 85721.
Infect Immun. 1993 Aug;61(8):3466-75. doi: 10.1128/iai.61.8.3466-3475.1993.
An in vivo model system for human campylobacteriosis has been developed in which colostrum-deprived newborn piglets are orally challenged with an invasive strain of Campylobacter jejuni. Piglets developed clinical symptoms and histopathological lesions similar to those observed in humans infected with C. jejuni. Gross lesion examination at autopsy revealed the presence of edema, hyperemia, and mucus. Histopathologic examinations by light and transmission electron microscopy demonstrated damage to surface epithelial cells with the presence of intracellular bacteria, mainly in the large intestine. Similar lesions were not demonstrated in control piglets.
已经开发出一种用于人类弯曲菌病的体内模型系统，其中初乳缺乏的新生仔猪经口感染空肠弯曲菌的侵袭性菌株。仔猪出现了与感染空肠弯曲菌的人类所观察到的相似的临床症状和组织病理学病变。尸检时的大体病变检查显示存在水肿、充血和黏液。通过光学显微镜和透射电子显微镜进行的组织病理学检查表明，表面上皮细胞受到损伤，细胞内存在细菌，主要位于大肠。对照仔猪未出现类似病变。
