Pfaller M A
Molecular Epidemiology and Fungus Testing Laboratory, Section of Medical Microbiology, Department of Pathology, Carver College of Medicine, College of Public Health, University of Iowa, Iowa City, IW 52242, USA.
Curr Drug Targets. 2005 Dec;6(8):929-43. doi: 10.2174/138945005774912708.
The number of systemically active antifungal agents has increased dramatically in recent years in response to the challenge of invasive mycoses. Additional work is needed to better understand the mechanisms of action of these agents as well as the mechanisms of resistance expressed by the fungal pathogens. Antifungal susceptibility testing has been standardized and refined and now may be considered to play an important role in the management of invasive mycoses. More work is needed to optimize the methods for testing new antifungal agents and for testing pathogens other than Candida. The ongoing efforts and international collaborations designed to address these issues will provide important information that will improve the management of serious fungal infections.
近年来，为应对侵袭性真菌病的挑战，全身活性抗真菌药物的数量急剧增加。需要开展更多工作，以更好地了解这些药物的作用机制以及真菌病原体表现出的耐药机制。抗真菌药敏试验已得到标准化和完善，目前可认为其在侵袭性真菌病的管理中发挥着重要作用。需要开展更多工作来优化测试新型抗真菌药物以及测试念珠菌以外病原体的方法。旨在解决这些问题的持续努力和国际合作将提供重要信息，从而改善严重真菌感染的管理。
