Saha Rumpa, Das Das Shukla, Kumar Ashwani, Kaur Iqbal R
Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
Indian J Pediatr. 2008 Aug;75(8):858-60. doi: 10.1007/s12098-008-0159-6. Epub 2008 Sep 4.
Nosocomial candidemia is the 4(th) most common pathogen in blood stream infection. Emergence of non-albicans Candida species with often intrinsically resistance fluconazole pattern may lead to difficulty in management of septicemia. Although the present study isolated 80% of non albicans candida species with C.tropicalis as the most common (35%) species, 96% of our Candida species isolated were sensitive to fluconazole. The probable causes of low resistance pattern to fluconazole in our institute are discussed. It is however necessary to identify the complete clinical response to the given treatment. Therefore, appropriate identification of species with susceptibility testing would be advisable before start of anti-fungals. This would prevent emergence of fluconazole resistance.
医院获得性念珠菌血症是血流感染中第四常见的病原体。非白色念珠菌属的出现，其往往具有对氟康唑的固有耐药模式，可能导致败血症管理困难。尽管本研究分离出80%的非白色念珠菌属，其中热带念珠菌是最常见的（35%）菌种，但我们分离出的念珠菌属中有96%对氟康唑敏感。本文讨论了我院氟康唑耐药率较低的可能原因。然而，有必要确定对给定治疗的完整临床反应。因此，在开始抗真菌治疗前，通过药敏试验进行菌种的适当鉴定是可取的。这将防止氟康唑耐药的出现。
