与滥用相关的创伤后应激障碍中前扣带回皮质体积较小。
Smaller volume of anterior cingulate cortex in abuse-related posttraumatic stress disorder.
作者信息
Kitayama Noriyuki, Quinn Sinead, Bremner J Douglas
机构信息
Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira-shi, Tokyo 187-8553, Japan.
出版信息
J Affect Disord. 2006 Feb;90(2-3):171-4. doi: 10.1016/j.jad.2005.11.006. Epub 2006 Jan 10.
Abstract
OBJECTIVE
The anterior cingulate cortex (ACC) plays an important role in emotion, and studies in animals have shown changes in ACC structure with early life stress. The purpose of this study was to measure volume of the ACC in PTSD.
METHOD
Magnetic resonance imaging (MRI) was used to measure ACC volume in 8 subjects with abuse-related PTSD and 13 healthy subjects without PTSD. ACC volume included Brodmann's area [BA] 24 and 32.
RESULTS
Right ACC volume in PTSD patients was significantly smaller than in non-PTSD subjects.
CONCLUSION
These results are consistent with smaller ACC volume in PTSD.
摘要
目的
前扣带回皮质（ACC）在情绪中起重要作用，动物研究表明早期生活应激会导致ACC结构发生变化。本研究的目的是测量创伤后应激障碍（PTSD）患者的ACC体积。
方法
使用磁共振成像（MRI）测量8名与虐待相关的PTSD患者和13名无PTSD的健康受试者的ACC体积。ACC体积包括布罗德曼区[BA]24和32。
结果
PTSD患者右侧ACC体积明显小于非PTSD受试者。
结论
这些结果与PTSD患者ACC体积较小一致。
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