Csaba Akos, Bush Melissa C, Saphier Carl
First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary, H-1088, Hungary.
Prenat Diagn. 2006 Jan;26(1):35-8. doi: 10.1002/pd.1323.
To compare the levels of pain and anxiety associated with amniocentesis (AC), transabdominal chorionic villus sampling (TA-CVS), and transcervical chorionic villus sampling (TC-CVS).
We prospectively administered a questionnaire about pain and anxiety to 124 women undergoing AC, 40 undergoing TA-CVS, and 24 undergoing TC-CVS for singleton pregnancies. The level of pain was quantified with numerical and pictorial scales and the degree of anxiety was quantified with a numerical scale (0-100 in increments of 10).
The mean pain score for TA-CVS, 41.4 +/- 18.1, was significantly higher than that for TC-CVS, 26.4 +/- 25.3, p = 0.008. The mean pain score for AC, 35.1 +/- 27.6, was intermediate. A higher degree of anxiety was associated with younger maternal age and nulliparity. A higher degree of anxiety was associated with a higher level of pain.
In general, each procedure is associated with a tolerable amount of pain. TA-CVS appears to be the most painful procedure while TC-CVS appears to be the least painful procedure. In certain groups of patients, the procedures may be associated with higher levels of pain and/or anxiety.
比较羊膜腔穿刺术（AC）、经腹绒毛取样术（TA-CVS）和经宫颈绒毛取样术（TC-CVS）相关的疼痛和焦虑水平。
我们前瞻性地对124例接受AC的单胎妊娠女性、40例接受TA-CVS的女性和24例接受TC-CVS的女性进行了关于疼痛和焦虑的问卷调查。疼痛程度用数字和图片量表进行量化，焦虑程度用数字量表（0-100，以10为增量）进行量化。
TA-CVS的平均疼痛评分41.4±18.1，显著高于TC-CVS的26.4±25.3，p = 0.008。AC的平均疼痛评分35.1±27.6，处于中间水平。较高程度的焦虑与较低的母亲年龄和未生育有关。较高程度的焦虑与较高水平的疼痛有关。
一般来说，每种操作都伴有可耐受的疼痛量。TA-CVS似乎是最痛苦的操作，而TC-CVS似乎是最不痛苦的操作。在某些患者群体中，这些操作可能与更高水平的疼痛和/或焦虑有关。
