McDonel J L, Asano T
Infect Immun. 1975 Mar;11(3):526-9. doi: 10.1128/iai.11.3.526-529.1975.
Net intestinal transport of sodium in vivo, in control and enterotoxin (Clostridium perfringens)-treated rats, was resolved into two unidirectional fluxes, influx from and efflux into the lumen of the terminal ileum. In rats treated with the toxin, sodium influx remained similar to control values even during fluid and electrolyte loss to the lumen. Net loss of sodium was shown to be due to nearly a twofold increase in sodium efflux to the lumen in toxin-treated animals. There was only slight histopathological damage to the mucosa, especially noticeable at the tips of villi.
在对照大鼠和经肠毒素（产气荚膜梭菌）处理的大鼠体内，回肠末端钠的净肠转运被分解为两个单向通量，即从肠腔流入和流出肠腔。在用毒素处理的大鼠中，即使在向肠腔丢失液体和电解质期间，钠的流入仍与对照值相似。钠的净损失表明是由于毒素处理的动物中钠向肠腔的流出增加了近两倍。黏膜仅有轻微的组织病理学损伤，在绒毛尖端尤为明显。
