产气荚膜梭菌肠毒素对大鼠外翻回肠囊代谢指标的影响
Effects of Clostridium perfringens enterotoxin on metabolic indexes of everted rat ileal sacs.
作者信息
McDonel J L, Duncan C L
出版信息
Infect Immun. 1975 Aug;12(2):274-80. doi: 10.1128/iai.12.2.274-280.1975.
Abstract
Everted sacs of rat ileum were incubated in Ringer phosphate solution while oxygen uptake, glucose uptake, and lactate production were determined. Sacs treated with Clostridium perfringens enterotoxin, in the form of crude cell-free extract and purified protein, consumed significantly less oxygen than untreated sacs. However, the toxin-treated sacs took up glucose and produced lactate at levels that were not significantly different than those observed in controls. We conclude that oxidative metabolism is inhibited by the action of the toxin, whereas conversion of glucose to lactate via glycolysis seems unaffected
摘要
将大鼠回肠外翻囊在磷酸林格液中孵育，同时测定耗氧量、葡萄糖摄取量和乳酸生成量。用产气荚膜梭菌肠毒素的粗无细胞提取物和纯化蛋白处理的囊，其耗氧量明显低于未处理的囊。然而，毒素处理的囊摄取葡萄糖和产生乳酸的水平与对照组相比无显著差异。我们得出结论，毒素的作用抑制了氧化代谢，而通过糖酵解将葡萄糖转化为乳酸的过程似乎未受影响。
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Effects of Clostridium perfringens enterotoxin on metabolic indexes of everted rat ileal sacs.产气荚膜梭菌肠毒素对大鼠外翻回肠囊代谢指标的影响
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本文引用的文献
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