Sumaya C V, Henle W, Henle G, Smith M H, LeBlanc D
J Infect Dis. 1975 Apr;131(4):403-8. doi: 10.1093/infdis/131.4.403.
The prevalence and titers of antibodies to capsid antigens of Epstein-Barr virus ad to the diffuse and restricted components of the Epstein-Barr virus-induced early antigen complex were determined in 109 families of a semirural community in Louisiana. Titers of antibody to the capsid antigens larger than or equal to 10 were found in 84 percent of children aged two to five years, and the prevalence increased with age to nearly 100 percent. There was a positive but variable correlation of the prevalence of anti-capsid antigen reactivity with low socioeconomic status and crowding. An overrepresentation of high titers of antibody to capsid antigens was present in individuals with a past history of pneumonia and urinary tract infections. The geometric mean titers of antibody to capsid antigens were highest in early childhood, lowest in adolescence and young adulthood, and high in the elderly. Females in all age groups and tonsillectomized children showed a higher geometric mean titer than their male and nontonsillectomized counterparts, respectively. Antibodies to the early antigen complex were found rarely (8.2 percent) and only in sera with relatively high titers of antibody to capsid antigens.
在路易斯安那州一个半乡村社区的109个家庭中，测定了针对爱泼斯坦-巴尔病毒衣壳抗原的抗体流行率和滴度，以及爱泼斯坦-巴尔病毒诱导的早期抗原复合物的弥散和局限成分。在2至5岁的儿童中，84%的儿童针对衣壳抗原的抗体滴度大于或等于10，且流行率随年龄增长而增加，接近100%。抗衣壳抗原反应性的流行率与低社会经济地位和拥挤程度呈正相关，但存在差异。有肺炎和尿路感染既往史的个体中，针对衣壳抗原的高滴度抗体比例过高。针对衣壳抗原的抗体几何平均滴度在幼儿期最高，在青春期和青年期最低，在老年人中较高。所有年龄组的女性和接受扁桃体切除术的儿童的几何平均滴度分别高于男性和未接受扁桃体切除术的儿童。针对早期抗原复合物的抗体很少被发现（8.2%），且仅存在于针对衣壳抗原抗体滴度相对较高的血清中。
