Flanagan Katie L, Buckley-Sharp Mark, Doherty Tom, Whitty Christopher J M
Hospital for Tropical Diseases, University College London Hospitals, London, UK.
Acta Trop. 2006 Feb;97(2):233-7. doi: 10.1016/j.actatropica.2005.11.006. Epub 2006 Jan 4.
Parenteral quinine is the most frequently used first line treatment for severe Plasmodium falciparum malaria in the developed world. Quinine is known to have a number of toxic side effects including cardiotoxicity, ototoxicity and ocular toxicity. Many therefore advocate routine monitoring of quinine levels for patients receiving parenteral therapy. This paper reviews current evidence on the usefulness of quinine level monitoring in the context of 73 adult patients with severe P. falciparum malaria managed by the Hospital for Tropical Diseases in London. Combining data from these patients with a comprehensive literature review, we conclude that routine quinine level monitoring in all patients receiving parenteral therapy is seldom appropriate.
在发达国家，胃肠外注射奎宁是治疗重症恶性疟原虫疟疾最常用的一线治疗方法。已知奎宁有许多毒副作用，包括心脏毒性、耳毒性和眼毒性。因此，许多人主张对接受胃肠外治疗的患者进行奎宁水平的常规监测。本文回顾了伦敦热带病医院对73例成年重症恶性疟原虫疟疾患者进行奎宁水平监测有效性的现有证据。将这些患者的数据与全面的文献综述相结合，我们得出结论，对所有接受胃肠外治疗的患者进行常规奎宁水平监测很少是合适的。
