将GIX胸腺细胞表面抗原与鼠白血病病毒的gp69/71包膜糖蛋白联系起来的生化证据。
Biochemical evidence linking the GIX thymocyte surface antigen to the gp69/71 envelope glycoprotein of murine leukemia virus.
作者信息
Tung J S, Vitetta E S, Fleissner E, Boyse E A
出版信息
J Exp Med. 1975 Jan 1;141(1):198-205. doi: 10.1084/jem.141.1.198.
Abstract
It is known that the thymocyte surface antigen GIX is found in some strains of mice and not others, and that its expression in mice of strain 129, in which most extensive genetic studies have been made, is controlled by two unlinked cellular chromosomal loci. We have now isolated a protein with a mol wt of approximately 70,000 daltons from the surface of thymocytes from 129 mice, which have antigenic and biochemical properties characteristic of the gp69/71 envelope component of murine leukemia virus. Our evidence is compatible with the conclusion that it carries the GIX antigen.
摘要
已知胸腺细胞表面抗原GIX在某些品系小鼠中存在，而在其他品系中不存在，并且在进行了最广泛遗传学研究的129品系小鼠中，其表达受两个不连锁的细胞染色体基因座控制。我们现已从129品系小鼠的胸腺细胞表面分离出一种分子量约为70,000道尔顿的蛋白质，该蛋白质具有鼠白血病病毒gp69/71包膜成分的抗原和生化特性。我们的证据支持它携带GIX抗原这一结论。
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