肿瘤病毒糖蛋白gp69/71：正常和恶性胸腺细胞表面的一种成分。
The oncornavirus glycoprotein gp69/71: a constituent of the surface of normal and malignant thymocytes.
作者信息
Del Vellano B C, Nave B, Croker B P, Lerner R A, Dixon F J
出版信息
J Exp Med. 1975 Jan 1;141(1):172-87. doi: 10.1084/jem.141.1.172.
The oncornavirus related proteins associated with the surface of normal and malignant thymocytes were studied. Three virion-associated proteins (gp69/71, p45, p30) were associated with lymphoma cells from about 70% of the tumors studied. Two virion-associated proteins (gp69/71 and p45 were associated with normal thymocytes form some but not all strains of mice. In gp69/71- mice, conversion to the gp69/71+ phenotype accompanied leukemogenesis. An interesting difference in the apparent molecular size of virus related antigens of the 70,000 dalton size class was detected in lymphoma cells present in involved spleens as compared to involved thymuses. Mice infected as neonates with Scripps leukemia virus make antibody to gp69/71 and some make antibodies to molecules associated with the surface of their own tumors. The significance of the restricted presence of antigens coded for by the viral genome to the surface of some differentiated cells is discussed in reference to (a) the relationship between virion, leukemia associated, and differentiation dependent markers, and (b) the possible consequence to the host of having similar antigenic determinants on three independent structures with replicative potential (virus, normal thymocytes, and tumor cells).
对与正常和恶性胸腺细胞表面相关的致癌RNA病毒蛋白进行了研究。在所研究的约70%的肿瘤中，三种病毒体相关蛋白（gp69/71、p45、p30）与淋巴瘤细胞相关。两种病毒体相关蛋白（gp69/71和p45）与部分但并非所有品系小鼠的正常胸腺细胞相关。在gp69/71基因缺失的小鼠中，向gp69/71阳性表型的转变伴随着白血病的发生。与受累胸腺中的淋巴瘤细胞相比，在受累脾脏中的淋巴瘤细胞中检测到70,000道尔顿大小类别的病毒相关抗原在表观分子大小上存在有趣的差异。新生时感染斯克里普斯白血病病毒的小鼠会产生针对gp69/71的抗体，有些还会产生针对其自身肿瘤表面相关分子的抗体。结合（a）病毒体、白血病相关标志物和分化依赖性标志物之间的关系，以及（b）在具有复制潜力的三种独立结构（病毒、正常胸腺细胞和肿瘤细胞）上具有相似抗原决定簇对宿主可能产生的后果，讨论了病毒基因组编码的抗原在某些分化细胞表面有限存在的意义。
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