Mollenhauer J, Schulmeister A
Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, Germany.
Experientia. 1992 Jul 15;48(7):644-9. doi: 10.1007/BF02118310.
Humoral immune reactions to heat shock proteins (hsp) from microorganisms are one aspect of microbial infections in humans. The production of antibodies which are specific to epitopes present on procaryotic hsp leads also to the appearance of cross-reactive serum antibodies in the host organism that react with human hsp. This article discusses the consequences of such autoreactive antibodies for the host in context with the development of immune tolerance and autoimmune diseases, especially rheumatoid arthritis (RA), and in experimental animal models for arthritis such as adjuvant arthritis in rats. On the basis of epitope cross-reactivity between hsp and other host proteins, a hypothesis is presented for the development of autoimmune disease following the production of hsp-specific antibodies.
针对微生物热休克蛋白（hsp）的体液免疫反应是人类微生物感染的一个方面。针对原核生物hsp上存在的表位产生的特异性抗体，也会导致宿主生物体中出现与人类hsp发生反应的交叉反应性血清抗体。本文结合免疫耐受和自身免疫性疾病（尤其是类风湿性关节炎，RA）的发展，以及大鼠佐剂性关节炎等关节炎实验动物模型，讨论了此类自身反应性抗体对宿主的影响。基于hsp与其他宿主蛋白之间的表位交叉反应性，提出了一个关于产生hsp特异性抗体后自身免疫性疾病发展的假说。
