Ernst Peter B, Peura David A, Crowe Sheila E
Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, Virginia 22908-0708, USA.
Gastroenterology. 2006 Jan;130(1):188-206; quiz 212-3. doi: 10.1053/j.gastro.2005.06.032.
In 1984, Barry Marshall and Robin Warren proposed a role for bacterial infections in the pathogenesis of gastroduodenal disease, which triggered an avalanche of research intended to prove or disprove their theory. The result has been a series of advances that have enhanced our understanding of these diseases and completely modernized the clinical approach to their management. In just over 20 years, many aspects of the immunopathogenesis of these diseases have been dissected at the molecular level, with key pathogenic mechanisms being validated by the identification of genes that are associated with the development of gastric cancer. There has been particular emphasis on understanding the molecular structures associated with Helicobacter pylori and their role in modifying the host responses. Gastric immune and inflammatory responses have emerged as key elements in the pathogenesis of gastritis and epithelial cell damage. This review summarizes important findings emanating from basic research primarily related to the immunopathogenesis of H pylori that have advanced the practice of medicine or our understanding of gastroduodenal disease.
1984年，巴里·马歇尔和罗宾·沃伦提出细菌感染在胃十二指肠疾病发病机制中起作用，这引发了一系列旨在证明或反驳他们理论的研究热潮。结果带来了一系列进展，增进了我们对这些疾病的理解，并使它们的临床治疗方法完全现代化。在短短20多年里，这些疾病免疫发病机制的许多方面已在分子水平上被剖析，关键致病机制通过鉴定与胃癌发生相关的基因而得到验证。尤其强调了对与幽门螺杆菌相关的分子结构及其在改变宿主反应中作用的理解。胃免疫和炎症反应已成为胃炎和上皮细胞损伤发病机制中的关键因素。本综述总结了基础研究的重要发现，这些发现主要与幽门螺杆菌的免疫发病机制相关，推动了医学实践或我们对胃十二指肠疾病的理解。
