Westerbeek H A, Mooi W J, Begg C, Dessing M, Balm A J
Department of ENT/Head and Neck Surgery, The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam.
Eur Arch Otorhinolaryngol. 1992;249(3):140-3. doi: 10.1007/BF00183488.
Flow cytometric DNA ploidy measurements using deparaffinized tumor specimens were performed on 46 squamous cell carcinomas of the head and neck, including 22 carcinomas of the oropharynx, 18 carcinomas of the larynx and six carcinomas of the oral cavity. Aneuploidy was found in 14 of these tumors with carcinomas of the larynx and oral cavity showing almost equal percentages of DNA aneuploidy (10/18 and 3/6, respectively). In contrast, only 1 of the oropharyngeal carcinomas was aneuploid. Accurate microscopy-controlled sampling of tumor tissue from the histological tissue blocks was found to be mandatory in order to obtain reliable ploidy measurements.
使用脱蜡肿瘤标本进行流式细胞术DNA倍体测量，对46例头颈部鳞状细胞癌进行了检测，其中包括22例口咽癌、18例喉癌和6例口腔癌。在这些肿瘤中，14例发现非整倍体，喉癌和口腔癌显示出几乎相等的DNA非整倍体百分比（分别为10/18和3/6）。相比之下，口咽癌中只有1例是非整倍体。为了获得可靠的倍体测量结果，发现从组织学组织块中准确地在显微镜控制下采集肿瘤组织是必不可少的。
