Eickholz Peter, Kim Ti-Sun, Schacher Beate, Reitmeir Peter, Bürklin Thomas, Ratka-Krüger Petra
Poliklinik für Parodontologie, Zentrum für Zahn-, Mund- und Kieferheilkunde, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt/Main, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.
Am J Dent. 2005 Dec;18(6):341-6.
To evaluate the clinical effects of topical subgingival application of a doxycycline gel compared to conventional mechanical debridement in supportive periodontal therapy.
37 patients with residual or recurring periodontitis after systematic periodontal treatment at two centers (Heidelberg, Frankfurt) participated in this study. They had to exhibit at least one single-rooted tooth with either a probing depth (PPD) = 5 mm and bleeding-on-probing (BOP) or with PPD > or = 6 mm. The patients were randomly assigned to one of the two different treatment regimes: DOXY (exclusively subgingival application of a 14% doxycycline gel) or SRP (scaling and root planing with a sonic scaler). Clinical examinations (plaque index [P1I], PPD, vertical relative attachment level [RAL-V], gingival index [GI]) were performed before, 3, and 6 months after therapy.
In 37 patients (19 female), aged 30-76 years with a total of 168 teeth were treated (DOXY: 79; SRP: 89). Six months after therapy, both groups exhibited statistically significant (P< 0.001) reductions of PPD (DOXY: -1.43 +/- 0.22 mm; SRP: -1.14 +/- 0.18 mm) and gains of RAL-V (DOXY: 0.79 +/- 0.22 mm; SRP: 0.72 +/- 0.19 mm). Multilevel regression analyses, considering the therapy of different numbers of teeth in different patients, failed to show statistically significant differences concerning PPD reduction and RAL-V gain between both therapies (DOXY/SRP). For both therapies, PPD reduction was significantly better in deeper pockets (PPD > or = 7 mm) than in shallow pockets (PPD: 5-6 mm).
评估在支持性牙周治疗中，与传统机械清创术相比，局部龈下应用强力霉素凝胶的临床效果。
来自两个中心（海德堡、法兰克福）的37例在接受系统性牙周治疗后仍有残余或复发性牙周炎的患者参与了本研究。他们必须至少有一颗单根牙，其探诊深度（PPD）=5mm且探诊出血（BOP），或PPD≥6mm。患者被随机分配到两种不同的治疗方案之一：强力霉素组（仅龈下应用14%强力霉素凝胶）或龈上洁治和根面平整组（使用声波洁治器进行龈上洁治和根面平整）。在治疗前、治疗后3个月和6个月进行临床检查（菌斑指数[P1I]、PPD、垂直相对附着水平[RAL-V]、牙龈指数[GI]）。
37例患者（19例女性），年龄30 - 76岁，共治疗168颗牙齿（强力霉素组：79颗；龈上洁治和根面平整组：89颗）。治疗6个月后，两组的PPD均有统计学显著降低（P<0.001）（强力霉素组：-1.43±0.22mm；龈上洁治和根面平整组：-1.14±0.18mm），RAL-V均有增加（强力霉素组：0.79±0.22mm；龈上洁治和根面平整组：0.72±0.19mm）。考虑到不同患者治疗牙齿数量不同进行的多水平回归分析，未能显示两种治疗方法（强力霉素组/龈上洁治和根面平整组）在PPD降低和RAL-V增加方面有统计学显著差异。对于两种治疗方法，较深牙周袋（PPD≥7mm）的PPD降低明显优于浅牙周袋（PPD：5 - 6mm）。
